Which sign indicates the need for monitoring after beginning desmopressin treatment?

The need for monitoring after beginning desmopressin treatment is primarily indicated by signs of water intoxication. Desmopressin is a synthetic analog of vasopressin (antidiuretic hormone) and is typically used to treat conditions like diabetes insipidus and certain bleeding disorders. One of its effects is to promote the retention of water by the kidneys, which can lead to an imbalance in fluid levels if not properly monitored.

Water intoxication can occur as a result of excessive water retention, leading to hyponatremia (low sodium levels in the blood). Symptoms of water intoxication may include headache, confusion, seizures, and in severe cases, coma. Therefore, monitoring for signs such as weight gain, changes in mental status, and edema is crucial in patients receiving desmopressin to prevent complications associated with excess fluid retention.

In contrast, fever, dry skin, and resolution of headache do not directly indicate the need for intensive monitoring in the context of desmopressin treatment. While these signs may signify other health issues or responses, they are not specifically associated with the adverse effects of desmopressin therapy that require close observation.